BTK PROTAC 9 ( —— )

Catalog No. M16947 CAS No.

COA

Datasheet

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Product Name

BTK PROTAC 9
Note

Research use only, not for human use.
Brief Description

BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells.
Description

BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK; TEC, a closely related protein to BTK that potently binds BTK PROTAC 9 is also degraded.
Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

--
Formula Weight

946.96
Molecular Formula

C46H52F2N8O12
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(N)N([C@H]2CN(C(COCCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)CCC2)N=C1C6=CC=C(OC7=CC=C(F)C=C7F)C=C6)N
Chemical Name

5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-(17-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12,15-pentaoxaheptadecan-1-oyl)piperidin-3-yl]-1H-pyrazole-4-carboxamide

1. Zorba A, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201803662.

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